Article
Simultaneous quantitative detection of afatinib, erlotinib, gefitinib, icotinib, osimertinib and their metabolites in plasma samples of patients with non-small cell lung cancer using liquid chromatography-tandem mass spectrometry.
Clinica chimica acta; international journal of clinical chemistry - 15 Feb 2022
Xiong Xin, Zhang Yuanyuan, Wang Ziyu, Zhou Congya, Yang Ping, Du Xin, Yang Li, Liu Wei
Abstract excerpt
BACKGROUND AND AIMS: As numerous studies have reported the concentration-exposure relationships of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs), therapeutic drug monitoring is a promising approach in lung cancer treatment, aiming to avoid treatment failure or toxicity. A new method for the simultaneous analysis of five EGFR-TKIs (afatinib, erlotinib, gefitinib, icotinib and osimertinib)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.