Article
Multiomic analysis of papillary thyroid cancers identifies BAIAP2L1-BRAF fusion and requirement of TRIM25, PDE5A and PKCδ for tumorigenesis.
Molecular cancer - 10 Oct 2022
Renaud Emilie, Riegel Kristina, Romero Rossana, Suryamohan Kushal, Distler Ute, Tenzer Stefan, Schad Arno, Musholt Thomas J, Rajalingam Krishnaraj
Abstract excerpt
BACKGROUND: Papillary thyroid carcinoma (PTC) is one of the most common forms of thyroid cancer with a cure rate of over 90% after surgery. However, aggressive forms may still occur, and personalized therapeutic strategies are increasingly required. METHODS: We performed integrated genomic and proteomic analysis of PTC tumor samples from patients who did not harbor BRAF or RAS mutations. We validate the analysis...
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