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Article

Acting on the CFTR Membrane-Spanning Domains Interface Rescues Some Misfolded Mutants.

International journal of molecular sciences - 19 Dec 2022

Baatallah Nesrine, Elbahnsi Ahmad, Chevalier Benoit, Castanier Solène, Mornon Jean-Paul, Pranke Iwona, Edelman Aleksander, Sermet-Gaudelus Isabelle, Callebaut Isabelle, Hinzpeter Alexandre

Abstract excerpt

ABC transporters are large membrane proteins sharing a complex architecture, which comprises two nucleotide-binding domains (NBDs) and two membrane-spanning domains (MSDs). These domains are susceptible to mutations affecting their folding and assembly. In the CFTR (ABCC7) protein, a groove has been highlighted in the MSD1 at the level of the membrane inner leaflet, containing both multiple mutations affecting...

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Identifiers

PMID: 36555865
DOI: 10.3390/ijms232416225
PMCID: PMC9780841

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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