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Article

CFTR: New insights into structure and function and implications for modulation by small molecules.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society - 1 Mar 2020

Kleizen Bertrand, Hunt John F, Callebaut Isabelle, Hwang Tzyh-Chang, Sermet-Gaudelus Isabelle, Hafkemeyer Sylvia, Sheppard David N

Abstract excerpt

Structural biology and functional studies are a powerful combination to elucidate fundamental knowledge about the cystic fibrosis transmembrane conductance regulator (CFTR). Here, we discuss the latest findings, including how clinically-approved drugs restore function to mutant CFTR, leading to better clinical outcomes for people with cystic fibrosis (CF). Despite the prospect of regulatory approval of a...

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Identifiers

PMID: 31759907
DOI: 10.1016/j.jcf.2019.10.021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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