Article
Parallel changes in gene expression after 20,000 generations of evolution in Escherichiacoli.
Proceedings of the National Academy of Sciences of the United States of America - 4 Feb 2003
Cooper Tim F, Rozen Daniel E, Lenski Richard E
Abstract excerpt
Twelve populations of Escherichia coli, derived from a common ancestor, evolved in a glucose-limited medium for 20,000 generations. Here we use DNA expression arrays to examine whether gene-expression profiles in two populations evolved in parallel, which would indicate adaptation, and to gain insight into the mechanisms underlying their adaptation. We compared the expression profile of the ancestor to that of...
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