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Cdt1 overexpression drives colorectal carcinogenesis through origin overlicensing and DNA damage

10 Oct 2022

Abstract excerpt

Chromatin licensing and DNA replication factor 1 (CDT1), a protein of the pre-replicative complex, is essential for loading the minichromosome maintenance complex (MCM) helicases onto the origins of DNA replication. While several studies have shown that dysregulation of CDT1 expression causes re-replication and DNA damage in cell lines, and CDT1 is highly expressed in several human cancers, whether CDT1...

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PMID: 36210634
DOI: 10.1002/path.6017

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