Article
A multi-omic analysis of MCF10A cells provides a resource for integrative assessment of ligand-mediated molecular and phenotypic responses.
Communications biology - 7 Oct 2022
Gross Sean M, Dane Mark A, Smith Rebecca L, Devlin Kaylyn L, McLean Ian C, Derrick Daniel S, Mills Caitlin E, Subramanian Kartik, London Alexandra B, Torre Denis, Evangelista John Erol, Clarke Daniel J B, Xie Zhuorui, Erdem Cemal, Lyons Nicholas, Natoli Ted, Pessa Sarah, Lu Xiaodong, Mullahoo James, Li Jonathan, Adam Miriam, Wassie Brook, Liu Moqing, Kilburn David F, Liby Tiera A, Bucher Elmar, Sanchez-Aguila Crystal, Daily Kenneth, Omberg Larsson, Wang Yunguan, Jacobson Connor, Yapp Clarence, Chung Mirra, Vidovic Dusica, Lu Yiling, Schurer Stephan, Lee Albert, Pillai Ajay, Subramanian Aravind, Papanastasiou Malvina, Fraenkel Ernest, Feiler Heidi S, Mills Gordon B, Jaffe Jake D, Ma'ayan Avi, Birtwistle Marc R, Sorger Peter K, Korkola James E, Gray Joe W, Heiser Laura M
Abstract excerpt
The phenotype of a cell and its underlying molecular state is strongly influenced by extracellular signals, including growth factors, hormones, and extracellular matrix proteins. While these signals are normally tightly controlled, their dysregulation leads to phenotypic and molecular states associated with diverse diseases. To develop a detailed understanding of the linkage between molecular and phenotypic...
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