The spike gene is a major determinant for the SARS-CoV-2 Omicron-BA.1 phenotype.

doi:10.1038/s41467-022-33632-y

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Article

The spike gene is a major determinant for the SARS-CoV-2 Omicron-BA.1 phenotype.

Nature communications - 7 Oct 2022

Barut G Tuba, Halwe Nico Joel, Taddeo Adriano, Kelly Jenna N, Schön Jacob, Ebert Nadine, Ulrich Lorenz, Devisme Christelle, Steiner Silvio, Trüeb Bettina Salome, Hoffmann Bernd, Veiga Inês Berenguer, Leborgne Nathan Georges François, Moreira Etori Aguiar, Breithaupt Angele, Wylezich Claudia, Höper Dirk, Wernike Kerstin, Godel Aurélie, Thomann Lisa, Flück Vera, Stalder Hanspeter, Brügger Melanie, Esteves Blandina I Oliveira, Zumkehr Beatrice, Beilleau Guillaume, Kratzel Annika, Schmied Kimberly, Ochsenbein Sarah, Lang Reto M, Wider Manon, Machahua Carlos, Dorn Patrick, Marti Thomas M, Funke-Chambour Manuela, Rauch Andri, Widera Marek, Ciesek Sandra, Dijkman Ronald, Hoffmann Donata, Alves Marco P, Benarafa Charaf, Beer Martin, Thiel Volker

Abstract excerpt

Variant of concern (VOC) Omicron-BA.1 has achieved global predominance in early 2022. Therefore, surveillance and comprehensive characterization of Omicron-BA.1 in advanced primary cell culture systems and animal models are urgently needed. Here, we characterize Omicron-BA.1 and recombinant Omicron-BA.1 spike gene mutants in comparison with VOC Delta in well-differentiated primary human nasal and bronchial...

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PMID: 36207334
DOI: 10.1038/s41467-022-33632-y
PMCID: PMC9543931

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