Article

SARS-CoV-2 Omicron spike mediated immune escape and tropism shift

2022-01-17

Abstract excerpt

<title>Abstract</title> <p>The SARS-CoV-2 Omicron BA.1 variant emerged in late 2021 and is characterised by multiple spike mutations across all spike domains. Here we show that Omicron BA.1 has higher affinity for ACE2 compared to Delta, and confers very significant evasion of therapeutic monoclonal and vaccine-elicited polyclonal neutralising antibodies after two doses. mRNA vaccination as a third vaccine dose r...

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Literature Corpus work: a002d7ef-9ff2-52ca-818a-e97f83616c63
DOI: 10.21203/rs.3.rs-1191837/v1

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