Article

SARS-CoV-2 Omicron spike mediated immune escape and tropism shift

2021-12-21

Abstract excerpt

The SARS-CoV-2 Omicron BA.1 variant emerged in late 2021 and is characterised by multiple spike mutations across all spike domains. Here we show that Omicron BA.1 has higher affinity for ACE2 compared to Delta, and confers very significant evasion of therapeutic monoclonal and vaccine-elicited polyclonal neutralising antibodies after two doses. mRNA vaccination as a third vaccine dose rescues and broadens neutrali...

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Literature Corpus work: 2c50b245-30c0-58de-a162-4ccd17ca88a1
DOI: 10.1101/2021.12.17.473248

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