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Article

Oncogenic roles of PRL‐3 in FLT3‐ITD induced acute myeloid leukaemia

8 Aug 2013

Abstract excerpt

FLT3-ITD mutations are prevalent mutations in acute myeloid leukaemia (AML). PRL-3, a metastasis-associated phosphatase, is a downstream target of FLT3-ITD. This study investigates the regulation and function of PRL-3 in leukaemia cell lines and AML patients associated with FLT3-ITD mutations. PRL-3 expression is upregulated by the FLT3-STAT5 signalling pathway in leukaemia cells, leading an activation of AP-1...

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PMID: 23929599
DOI: 10.1002/emmm.201202183

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