Article
Overview and clinical significance of multiple mutations in individual genes in hepatocellular carcinoma.
BMC cancer - 5 Oct 2022
Imamura Taisuke, Okamura Yukiyasu, Ohshima Keiichi, Uesaka Katsuhiko, Sugiura Teiichi, Ito Takaaki, Yamamoto Yusuke, Ashida Ryo, Ohgi Katsuhisa, Otsuka Shimpei, Ohnami Sumiko, Nagashima Takeshi, Hatakeyama Keiichi, Sugino Takashi, Urakami Kenichi, Akiyama Yasuto, Yamaguchi Ken
Abstract excerpt
BACKGROUND: Multiple mutation (MM) within a single gene has recently been reported as a mechanism involved in carcinogenesis. The present study investigated the clinical significance of MMs in hepatocellular carcinoma (HCC). METHODS: Two hundred twenty-three surgically resected HCCs were subjected to gene expression profiling and whole-exome sequencing. RESULTS: MMs in individual genes were detected in 178...
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