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Article

NMR-guided directed evolution.

Nature - 1 Oct 2022

Bhattacharya Sagar, Margheritis Eleonora G, Takahashi Katsuya, Kulesha Alona, D'Souza Areetha, Kim Inhye, Yoon Jennifer H, Tame Jeremy R H, Volkov Alexander N, Makhlynets Olga V, Korendovych Ivan V

Abstract excerpt

Directed evolution is a powerful tool for improving existing properties and imparting completely new functionalities to proteins1-4. Nonetheless, its potential in even small proteins is inherently limited by the astronomical number of possible amino acid sequences. Sampling the complete sequence space of a 100-residue protein would require testing of 20100 combinations, which is beyond any existing experimental...

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Identifiers

PMID: 36198791
DOI: 10.1038/s41586-022-05278-9
PMCID: PMC10116341

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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