Article
Polymorphisms of the BCL2 gene associated with susceptibility to tuberculosis.
Revista do Instituto de Medicina Tropical de Sao Paulo - 1 Jan 2022
He Juan, Liu Shengyuan, Guo Xujun, Zhang Fan, Takiff Howard Eugene, Zhao Yashuang
Abstract excerpt
Although tuberculosis (TB) is a serious public health concern, we still don't understand why only 10% of people infected will develop the disease. Apoptosis plays a role in the interaction of Mycobacterium tuberculosis (Mtb) with the human host and it may be modified by subtle alterations in the B-cell lymphoma 2 (BCL2) gene, an anti-apoptotic regulatory element. Therefore, we investigated whether there is an...
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