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Article

Detection of circulating tumour DNA after neoadjuvant chemoradiotherapy in patients with locally advanced oesophageal cancer.

The Journal of pathology - 1 Jan 2023

Eyck Ben M, Jansen Maurice Phm, Noordman Bo Jan, Atmodimedjo Peggy N, van der Wilk Berend J, Martens John Wm, Helmijr Jean A, Beaufort Corine M, Mostert Bianca, Doukas Michail, Wijnhoven Bas Pl, Lagarde Sjoerd M, van Lanschot J Jan B, Dinjens Winand Nm

Abstract excerpt

Active surveillance instead of standard surgery after neoadjuvant chemoradiotherapy (nCRT) has been proposed for patients with oesophageal cancer. Circulating tumour DNA (ctDNA) may be used to facilitate selection of patients for surgery. We show that detection of ctDNA after nCRT seems highly suggestive of major residual disease. Tumour biopsies and blood samples were taken before, and 6 and 12 weeks after,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36196486
DOI: 10.1002/path.6016
PMCID: PMC10092085

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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