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White blood cell and cell-free DNA analyses for detection of residual disease in gastric cancer

27 Jan 2020

Abstract excerpt

Liquid biopsies are providing new opportunities for detection of residual disease in cell-free DNA (cfDNA) after surgery but may be confounded through identification of alterations arising from clonal hematopoiesis. Here, we identify circulating tumor-derived DNA (ctDNA) alterations through ultrasensitive targeted sequencing analyses of matched cfDNA and white blood cells from the same patient. We apply this...

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PMID: 31988276
DOI: 10.1038/s41467-020-14310-3

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