Article
Meta-GWAS identifies the heritability of acute radiation-induced toxicities in head and neck cancer.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology - 1 Nov 2022
Naderi Elnaz, Schack Line M H, Welsh Ceilidh, Sim Adelene Y L, Aguado-Barrera Miguel E, Dudding Tom, Summersgil Holly, Martínez-Calvo Laura, Ong Enya H W, Odding Yasmin, Varela-Pazos Ana, Steenbakkers Roel J H M, Crijns Anne P G, Jena Rajesh, Pring Miranda, Dennis Joe, Lobato-Busto Ramón, Alsner Jan, Ness Andy, Nutting Christopher, Thomson David J, Gómez-Caamaño Antonio, Eriksen Jesper G, Thomas Steve J, Bates Amy M, Overgaard Jens, Cascallar-Caneda Luis M, Duprez Fréderic, Barnett Gillian C, Dorling Leila, Chua Melvin L K, Vega Ana, West Catharine M L, Langendijk Johannes A, Nicolaj Andreassen Christian, Alizadeh Behrooz Z
Abstract excerpt
BACKGROUND AND PURPOSE: We aimed to the genetic components and susceptibility variants associated with acute radiation-induced toxicities (RITs) in patients with head and neck cancer (HNC). MATERIALS AND METHODS: We performed the largest meta-GWAS of seven European cohorts (n = 4,042). Patients were scored weekly during radiotherapy for acute RITs including dysphagia, mucositis, and xerostomia. We analyzed the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.