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Article

Genome-wide association study identifies genetic susceptibility loci and pathways of radiation-induced acute oral mucositis.

Journal of translational medicine - 5 Jun 2020

Yang Da-Wei, Wang Tong-Min, Zhang Jiang-Bo, Li Xi-Zhao, He Yong-Qiao, Xiao Ruowen, Xue Wen-Qiong, Zheng Xiao-Hui, Zhang Pei-Fen, Zhang Shao-Dan, Hu Ye-Zhu, Shen Guo-Ping, Chen Mingyuan, Sun Ying, Jia Wei-Hua

Abstract excerpt

BACKGROUND: Radiation-induced oral mucositis (OM) is one of the most common acute complications for head and neck cancer. Severe OM is associated with radiation treatment breaks, which harms successful tumor management. Radiogenomics studies have indicated that genetic variants are associated with adverse effects of radiotherapy. METHODS: A large-scale genome-wide scan was performed in 1467 nasopharyngeal...

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Effects of Radiation Exposure
Genetic Predisposition to Disease
Genome-Wide Association Study
Glutathione Transferases and Polymorphisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nasopharyngeal Carcinoma

Nasopharyngeal Neoplasms

Oral health in cancer treatment

Polymorphism, Single Nucleotide

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Identifiers

PMID: 32503578
DOI: 10.1186/s12967-020-02390-0
PMCID: PMC7275566

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