Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Controlling hypothalamic DNA methylation at the Pomc promoter does not regulate weight gain during the development of obesity

10 Apr 2023

Abstract excerpt

Obesity is a complex medical condition that is linked to various health complications such as infertility, stroke, and osteoarthritis. Understanding the neurobiology of obesity is crucial for responding to the etiology of this disease. The hypothalamus coordinates many integral activities such as hormone regulation and feed intake and numerous studies have observed altered hypothalamic gene regulation in obesity...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dietary Effects on Health
Share to Epigenetics and DNA Methylation
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37036864
DOI: 10.1371/journal.pone.0284286

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Controlling hypothalamic DNA methylation at the Pomc promoter does not regulate weight gain during the development of obesityPMID 37036864Read ↗

DNA Methylation in the Hypothalamic Feeding Center and ObesitySemantic proximity Read ↗

Epigenetic regulation of POMC; implications for nutritional programming, obesity and metabolic diseaseSemantic proximity Read ↗

Diet‐induced DNA methylation within the hypothalamic arcuate nucleus and dysregulated leptin and insulin signaling in the pathophysiology of obesitySemantic proximity Read ↗

Early-set POMC methylation variability is accompanied by increased risk for obesity and is addressable by MC4R agonist treatmentSemantic proximity Read ↗

Molecular and functional genetics of the proopiomelanocortin gene, food intake regulation and obesitySemantic proximity Read ↗

The increase in body weight induced by lack of methyl CpG binding protein-2 is associated with altered leptin signalling in the hypothalamus.Semantic proximity Read ↗

DNA CpG Methylation (5-Methylcytosine) and Its Derivative (5-Hydroxymethylcytosine) Alter Histone Posttranslational Modifications at the <i>Pomc</i> Promoter, Affecting the Impact of Perinatal Diet on Leanness and Obesity of the OffspringSemantic proximity Read ↗

In Vivo Reductionist Approach Identifies miR-15a Protecting Mice From ObesitySemantic proximity Read ↗

Promoter or enhancer activation by CRISPRa rescues haploinsufficiency caused obesitySemantic proximity Read ↗

TET3 epigenetically controls feeding and stress response behaviors via AGRP neuronsSemantic proximity Read ↗

The neuroendocrine circuitry controlled by POMC, MSH, and AGRP.Semantic proximity Read ↗

POMC-specific knockdown of MeCP2 leads to adverse phenotypes in mice chronically exposed to high fat diet.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.