Hepatocellular Carcinoma in Mongolia Delineates Unique Molecular Traits and a Mutational Signature Associated with Environmental Agents.

doi:10.1158/1078-0432.CCR-22-0632

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Article

Hepatocellular Carcinoma in Mongolia Delineates Unique Molecular Traits and a Mutational Signature Associated with Environmental Agents.

Clinical cancer research : an official journal of the American Association for Cancer Research - 14 Oct 2022

Torrens Laura, Puigvehí Marc, Torres-Martín Miguel, Wang Huan, Maeda Miho, Haber Philipp K, Leonel Thais, García-López Mireia, Esteban-Fabró Roger, Leow Wei Qiang, Montironi Carla, Torrecilla Sara, Varadarajan Ajay Ramakrishnan, Taik Patricia, Campreciós Genís, Enkhbold Chinbold, Taivanbaatar Erdenebileg, Yerbolat Amankyeldi, Villanueva Augusto, Pérez-Del-Pulgar Sofía, Thung Swan, Chinburen Jigjidsuren, Letouzé Eric, Zucman-Rossi Jessica, Uzilov Andrew, Neely Jaclyn, Forns Xavier, Roayaie Sasan, Sia Daniela, Llovet Josep M

Abstract excerpt

PURPOSE: Mongolia has the world's highest incidence of hepatocellular carcinoma (HCC), with ∼100 cases/100,000 inhabitants, although the reasons for this have not been thoroughly delineated. EXPERIMENTAL DESIGN: We performed a molecular characterization of Mongolian (n = 192) compared with Western (n = 187) HCCs by RNA sequencing and whole-exome sequencing to unveil distinct genomic and transcriptomic features...

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PMID: 35998012
DOI: 10.1158/1078-0432.CCR-22-0632
PMCID: PMC7613712

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