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Article

Extracellular matrix stiffness controls cardiac valve myofibroblast activation through epigenetic remodeling

12 Aug 2022

Abstract excerpt

Aortic valve stenosis (AVS) is a progressive fibrotic disease that is caused by thickening and stiffening of valve leaflets. At the cellular level, quiescent valve interstitial cells (qVICs) activate to myofibroblasts (aVICs) that persist within the valve tissue. Given the persistence of myofibroblasts in AVS, epigenetic mechanisms have been implicated. Here, we studied changes that occur in VICs during...

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Share to Cardiac Fibrosis and Remodeling
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PMID: 36176599
DOI: 10.1002/btm2.10394

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