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Genetic risk score is associated with T2DM and diabetes complications risks.

Gene - 15 Jan 2023

Hubacek Jaroslav A, Dlouha Lucie, Adamkova Vera, Dlouha Dana, Pacal Lukas, Kankova Katerina, Galuska David, Lanska Vera, Veleba Jiri, Pelikanova Terezie

Abstract excerpt

BACKGROUND: Type 2 diabetes mellitus (T2DM) is a prototypical complex disease with polygenic architecture playing an important role in determining susceptibility to develop the disease (and its complications) in subjects exposed to modifiable lifestyle factors. A current challenge is to quantify the degree of the individual's genetic risk using genetic risk scores (GRS) capturing the results of genome-wide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36174902
DOI: 10.1016/j.gene.2022.146921

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