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Article

KATP Channel Pharmacogenomics: From Bench to Bedside

24 Oct 2007

Abstract excerpt

Inheritance plays a significant role in defining drug response and toxicity. Advances in molecular pharmacology and modern genomics emphasize genetic variation in dictating inter-individual pharmacokinetics and pharmacodynamics. A case in point is the homeostatic ATP-sensitive potassium (K(ATP)) channel, an established drug target that adjusts membrane excitability to match cellular energetic demand. There is an...

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PMID: 17957187
DOI: 10.1038/sj.clpt.6100378

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