Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

AlloMAPS 2: allosteric fingerprints of the AlphaFold and Pfam-trRosetta predicted structures for engineering and design.

Nucleic acids research - 6 Jan 2023

Tan Zhen Wah, Tee Wei-Ven, Guarnera Enrico, Berezovsky Igor N

Abstract excerpt

AlloMAPS 2 is an update of the Allosteric Mutation Analysis and Polymorphism of Signalling database, which contains data on allosteric communication obtained for predicted structures in the AlphaFold database (AFDB) and trRosetta-predicted Pfam domains. The data update contains Allosteric Signalling Maps (ASMs) and Allosteric Probing Maps (APMs) quantifying allosteric effects of mutations and of small probe...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Allosteric Regulation
Share to Databases, Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Design

Share to Mutation

Share to Proteins

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 36169226
DOI: 10.1093/nar/gkac828
PMCID: PMC9825619

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

AlloMAPS 2: allosteric fingerprints of the AlphaFold and Pfam-trRosetta predicted structures for engineering and design.PMID 36169226Read ↗

AlloSigMA 2: paving the way to designing allosteric effectors and to exploring allosteric effects of mutations.Semantic proximity Read ↗

AlloSigMA: allosteric signaling and mutation analysis server.Semantic proximity Read ↗

Functional plasticity and evolutionary adaptation of allosteric regulation.Semantic proximity Read ↗

Predicting Mutation-Induced Allosteric Changes in Structures and Conformational Ensembles of the ABL Kinase Using AlphaFold2 Adaptations with Alanine Sequence Scanning.Semantic proximity Read ↗

Global mapping of the energetic and allosteric landscapes of protein binding domainsSemantic proximity Read ↗

The origin of allosteric functional modulation: multiple pre-existing pathways.Semantic proximity Read ↗

Deep mutational scanning and machine learning reveal structural and molecular rules governing allosteric hotspots in homologous proteins.Semantic proximity Read ↗

Conservation and divergence in the allosteric architectures of five human protein kinasesSemantic proximity Read ↗

GPCR-MAPS: high-resolution functional and allosteric mapping of G protein-coupled receptor activation and biasSemantic proximity Read ↗

Probing Functional Allosteric States and Conformational Ensembles of the Allosteric Protein Kinase States and Mutants: Atomistic Modeling and Comparative Analysis of AlphaFold2, OmegaFold, and AlphaFlow Approaches and Adaptations.Semantic proximity Read ↗

Supertertiary protein structure affects an allosteric network.Semantic proximity Read ↗

GPCRdb in 2023: state-specific structure models using AlphaFold2 and new ligand resources.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.