Article
Tumor genotype, location, and malignant potential shape the immunogenicity of primary untreated gastrointestinal stromal tumors.
JCI insight - 19 Nov 2020
Gasparotto Daniela, Sbaraglia Marta, Rossi Sabrina, Baldazzi Davide, Brenca Monica, Mondello Alessia, Nardi Federica, Racanelli Dominga, Cacciatore Matilde, Dei Tos Angelo Paolo, Maestro Roberta
Abstract excerpt
Intratumoral immune infiltrate was recently reported in gastrointestinal stromal tumors (GISTs). However, the tumor-intrinsic factors that dictate GIST immunogenicity are still largely undefined. To shed light on this issue, a large cohort (82 samples) of primary untreated GISTs, representative of major clinicopathological variables, was investigated by an integrated immunohistochemical, transcriptomic, and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.