Article
Gastrointestinal Stromal Tumors (GISTs): Novel Therapeutic Strategies with Immunotherapy and Small Molecules.
International journal of molecular sciences - 6 Jan 2021
Vallilas Christos, Sarantis Panagiotis, Kyriazoglou Anastasios, Koustas Evangelos, Theocharis Stamatios, Papavassiliou Athanasios G, Karamouzis Michalis V
Abstract excerpt
Gastrointestinal stromal tumors (GISTs) are the most common types of malignant mesenchymal tumors in the gastrointestinal tract, with an estimated incidence of 1.5/100.000 per year and 1-2% of gastrointestinal neoplasms. About 75-80% of patients have mutations in the KIT gene in exons 9, 11, 13, 14, 17, and 5-10% of patients have mutations in the platelet-derived growth factor receptor a (PDGFRA) gene in exons...
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