Article
Systemic Therapy for Gastrointestinal Stromal Tumor: Current Standards and Emerging Challenges.
Current treatment options in oncology - 1 Sept 2022
Huang Wen-Kuan, Wu Chiao-En, Wang Shang-Yu, Chang Ching-Fu, Chou Wen-Chi, Chen Jen-Shi, Yeh Chun-Nan
Abstract excerpt
OPINION STATEMENT: Gastrointestinal stromal tumor (GIST), though rare, is the most common mesenchymal tumors of the gastrointestinal tract. KIT or PDGFRα mutation plays as an oncogenic driver in the majority of GISTs. Surgical resection is the only curative treatment for localized disease. The discovery of imatinib with promising anti-tumor effect and successive tyrosine kinase inhibitors (TKI), including...
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