Article
Correlation of plasma cell assessment by phenotypic methods and molecular profiles by NGS in patients with plasma cell dyscrasias.
BMC medical genomics - 23 Sept 2022
Rebmann Chigrinova Ekaterina, Porret Naomi A, Andres Martin, Wiedemann Gertrud, Banz Yara, Legros Myriam, Pollak Matthias, Oppliger Leibundgut Elisabeth, Pabst Thomas, Bacher Ulrike
Abstract excerpt
BACKGROUND: Next-generation sequencing (NGS) detects somatic mutations in a high proportion of plasma cell dyscrasias (PCD), but is currently not integrated into diagnostic routine. We correlated NGS data with degree of bone marrow (BM) involvement by cytomorphology (BMC), histopathology (BMH), and multiparameter flow cytometry (MFC) in 90 PCD patients. METHODS: Of the 90 patients the diagnoses comprised multiple...
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