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Plasma cell leukemia: genomic features and their potential relevance for exploring clinical actionability.

Blood advances - 24 Feb 2026

Mohan Meera, Danziger Natalie, Akhtar Othman Salim, Narra Ravi, Pasquini Marcello C, Radhakrishnan Sabarinath, Dhakal Binod, D'Souza Anita, Lin Douglas, Ho Caleb, Kurzrock Razelle

Abstract excerpt

ABSTRACT: Plasma cell leukemia (PCL) is rare and aggressive. Plasma cells from patients with PCL were examined using next-generation sequencing (NGS). We compared NGS data from 18 patients with PCL (peripheral blood, n = 10; bone marrow, n = 8) and 1742 multiple myeloma (MM) samples. Mutations of TP53, CCND1, and KRAS were commonly observed in both diseases. Alterations in DIS3 (17% vs 1%), CCND2 (22% vs 15%),...

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Identifiers

PMID: 41411484
DOI: 10.1182/bloodadvances.2025018342
PMCID: PMC12927052

Genes

CCND1
IGH
BRAF
CCND2
DIS3
KRAS
MAP3K1
MYC
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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