Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The SARS-CoV-2 Omicron BA.1 spike G446S mutation potentiates antiviral T-cell recognition.

Nature communications - 21 Sept 2022

Motozono Chihiro, Toyoda Mako, Tan Toong Seng, Hamana Hiroshi, Goto Yoshihiko, Aritsu Yoshiki, Miyashita Yusuke, Oshiumi Hiroyuki, Nakamura Kimitoshi, Okada Seiji, Udaka Keiko, Kitamatsu Mizuki, Kishi Hiroyuki, Ueno Takamasa

Abstract excerpt

Although the Omicron variant of the SARS-CoV-2 virus shows resistance to neutralizing antibody, it retains susceptibility to the cellular immune response. Here we characterize vaccine-induced T cells specific for various SARS-CoV-2 variants and identified HLA-A*24:02-restricted CD8+ T cells that strongly suppress Omicron BA.1 replication in vitro. Mutagenesis analyses revealed that a G446S mutation, located just...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Neutralizing
Share to Antibodies, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD8-Positive T-Lymphocytes

Share to COVID-19

Share to Epitopes

Share to Receptors, Antigen, T-Cell

Share to SARS-CoV-2

Share to Spike Glycoprotein, Coronavirus

Source

Open in PubMed Open full text

Identifiers

PMID: 36130929
DOI: 10.1038/s41467-022-33068-4
PMCID: PMC9492656

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The SARS-CoV-2 Omicron BA.1 spike G446S mutation potentiates antiviral T-cell recognition.PMID 36130929Read ↗

Ablation of CD8+ T cell recognition of an immunodominant epitope in SARS-CoV-2 Omicron variants BA.1, BA.2 and BA.3Semantic proximity Read ↗

SARS-CoV-2 Omicron (BA.1 and BA.2) specific novel CD8+ and CD4+ T cell epitopes targeting spike proteinSemantic proximity Read ↗

Omicron BA.1 Mutations in SARS-CoV-2 Spike Lead to Reduced T-Cell Response in Vaccinated and Convalescent Individuals.Semantic proximity Read ↗

T cell reactivity to the SARS-CoV-2 Omicron variant is preserved in most but not all individualsSemantic proximity Read ↗

SARS-CoV-2 Omicron BA.4/BA.5 Mutations in Spike Leading to T Cell Escape in Recently Vaccinated Individuals.Semantic proximity Read ↗

Ablation of CD8+ T-cell recognition of an immunodominant epitope in SARS-CoV-2 OmicronSemantic proximity Read ↗

SARS-CoV-2 T Cell Responses Elicited by COVID-19 Vaccines or Infection Are Expected to Remain Robust against Omicron.Semantic proximity Read ↗

SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathwaySemantic proximity Read ↗

Extensive cross-reactive T cell epitopes across SARS-CoV-2 Omicron variant spikes with finite immune evasion mutations.Semantic proximity Read ↗

Landscape of T cell epitopes displays hot mutations of SARS-CoV-2 variant spikes evading cellular immunity.Semantic proximity Read ↗

Role of spike in the pathogenic and antigenic behavior of SARS-CoV-2 BA.1 OmicronSemantic proximity Read ↗

Omicron Reactive Multi Protein Specific CD4 T Cells Defines Cellular Immune Response Induced by Inactivated Virus VaccinesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.