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Article

Pore formation‐independent cell death induced by a β‐barrel pore‐forming toxin

20 Sept 2022

Abstract excerpt

Vibrio cholerae cytolysin (VCC) is a β-barrel pore-forming toxin (β-PFT). It exhibits potent hemolytic activity against erythrocytes that appears to be a direct outcome of its pore-forming functionality. However, VCC-mediated cell-killing mechanism is more complicated in the case of nucleated mammalian cells. It induces apoptosis in the target nucleated cells, mechanistic details of which are still unclear....

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PMID: 36125006
DOI: 10.1096/fj.202200788r

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