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Deletion of mdig enhances H3K36me3 and metastatic potential of the triple negative breast cancer cells

3 Sept 2022

Abstract excerpt

In this report, we provide evidence showing diminished expression of the mineral dust-induced gene (mdig), a previously identified oncogenic gene, in human triple negative breast cancer (TNBC). Using a mouse model of orthotopic xenograft of the TNBC MDA-MB-231 cells, we demonstrate that mdig promotes the growth of primary tumors but inhibits metastasis of these cells in vivo . Knockout of mdig resulted in an...

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PMID: 36124233
DOI: 10.1016/j.isci.2022.105057

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