Article
Mutant p53 drives invasion in breast tumors through up-regulation of miR-155.
Oncogene - 13 Jun 2013
Neilsen P M, Noll J E, Mattiske S, Bracken C P, Gregory P A, Schulz R B, Lim S P, Kumar R, Suetani R J, Goodall G J, Callen D F
Abstract excerpt
Loss of p53 function is a critical event during tumorigenesis, with half of all cancers harboring mutations within the TP53 gene. Such events frequently result in the expression of a mutated p53 protein with gain-of-function properties that drive invasion and metastasis. Here, we show that the expression of miR-155 was up-regulated by mutant p53 to drive invasion. The miR-155 host gene was directly repressed by...
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