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Integrated stem cell signature and cytomolecular risk determination in pediatric acute myeloid leukemia

19 Sept 2022

Abstract excerpt

Relapsed or refractory pediatric acute myeloid leukemia (AML) is associated with poor outcomes and relapse risk prediction approaches have not changed significantly in decades. To build a robust transcriptional risk prediction model for pediatric AML, we perform RNA-sequencing on 1503 primary diagnostic samples. While a 17 gene leukemia stem cell signature (LSC17) is predictive in our aggregated pediatric study...

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PMID: 36123353
DOI: 10.1038/s41467-022-33244-6

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