Article

B cell repertoire of children with atopic dermatitis exhibit altered IgE maturation associated with allergic food sensitization

2023-02-03

Abstract excerpt

IgE B cells produce antibodies responsible for the inappropriate specificity seen in allergic disease. In this study, we sequence antibody gene repertoires from a large, well-characterized early life cohort at risk for developing food allergy. We found that food allergen sensitization was associated with lower IgE mutation frequencies that was abrogated in children living with a pet dog, suggesting potential molec...

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Literature Corpus work: 915b0145-3258-5b9c-87dc-980f7ab34742
DOI: 10.1101/2023.02.01.526538

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