Article
B-Cell Repertoire of Children With Atopic Dermatitis Exhibits Altered IgE Maturation Associated With Allergic Food Sensitization.
Allergy - 1 Feb 2026
Gill Kirandeep K, Moore Carolina, Nwogu Onyekachi, Kroner John W, Chang Wan-Chi, Burkle Jeffrey, Virolainen Samuel J, Stevens Mariana L, Baatyrbek Asel, Miraldi Emily R, Biagini Jocelyn M, Devonshire Ashley L, Kottyan Leah, Schwartz Justin T, Assa'ad Amal H, Martin Lisa J, Andorf Sandra, Khurana Hershey Gurjit K, Roskin Krishna M
Abstract excerpt
IgE B cells produce antibodies responsible for the inappropriate specificity seen in allergic disease. In this study, we sequence antibody gene repertoires from a large, well-characterized early life cohort at risk for developing food allergy. We found that food allergen sensitization was associated with lower IgE mutation frequencies that was abrogated in children living with a pet dog, suggesting potential...
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