Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lineage switching of the cellular distribution of BRAFV600E in multisystem Langerhans cell histiocytosis.

Blood advances - 23 May 2023

Milne Paul, Bomken Simon, Slater Olga, Kumar Ashish, Nelson Adam, Roy Somak, Velazquez Jessica, Mankad Kshitij, Nicholson James, Yeomanson Dan, Grundy Richard, Kamal Ahmed, Penn Anthony, Pears Jane, Millen Gerard, Morland Bruce, Hayden James, Lam Jason, Madkhali Maymoon, MacDonald Jamie, Singh Preeti, Pagan Sarah, Rodriguez-Galindo Carlos, Minkov Milen, Donadieu Jean, Picarsic Jennifer, Allen Carl, Bigley Venetia, Collin Matthew

Abstract excerpt

Most children with high-risk Langerhans cell histiocytosis (LCH) have BRAFV600E mutation. BRAFV600E alleles are detectable in myeloid mononuclear cells at diagnosis but it is not known if the cellular distribution of mutation evolves over time. Here, the profiles of 16 patients with high-risk dis...

Topics

Humans
Dendritic Cells
Histiocytosis, Langerhans-Cell
Leukocytes, Mononuclear
Monocytes
Mutation
Male
Female
Infant
Child, Preschool

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

T-Lymphocytes

Cell Lineage

Proto-Oncogene Proteins B-raf

Source

Open in PubMed Open full text

Identifiers

PMID: 36112425
DOI: 10.1182/bloodadvances.2021006732
PMCID: PMC10196915

Genes

CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-36112425-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lineage switching of the cellular distribution of BRAFV600E in multisystem Langerhans cell histiocytosis.PMID 36112425Read ↗

BRAF Mutation Correlates With High-Risk Langerhans Cell Histiocytosis and Increased Resistance to First-Line Therapy.Semantic proximity Read ↗

BRAF-V600E mutations in plasma and peripheral blood mononuclear cells correlate with prognosis of pediatric Langerhans cell histiocytosis treated with first-line therapy.Semantic proximity Read ↗

Clinicogenomic associations in childhood Langerhans cell histiocytosis: an international cohort study.Semantic proximity Read ↗

Circulating cell-free BRAFV600E as a biomarker in children with Langerhans cell histiocytosis.Semantic proximity Read ↗

Early association of Vemurafenib to standard chemotherapy in multisystemic Langerhans cell histiocytosis in a newborn: take the chance for a better outcome?Semantic proximity Read ↗

BRAF deletion in adult patients with Langerhans cell histiocytosis correlates with multisystem disease and poor outcomeSemantic proximity Read ↗

Clinical and prognostic features of Langerhans cell histiocytosis in adults.Semantic proximity Read ↗

Advances in our understanding of genetic markers and targeted therapies for pediatric LCH.Semantic proximity Read ↗

<i>BRAF</i> V600E mutation correlates with suppressive tumor immune microenvironment and reduced disease-free survival in Langerhans cell histiocytosisSemantic proximity Read ↗

BRAF Deletion in Adult Patients with Langerhans Cell Histiocytosis Correlates with Multisystem Disease and Poor Outcomes.Semantic proximity Read ↗

BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups.Semantic proximity Read ↗

High-risk LCH in infants is serially transplantable in a xenograft model but responds durably to targeted therapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.