BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups.

doi:10.1084/jem.20130977

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Article

BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups.

The Journal of experimental medicine - 7 Apr 2014

Berres Marie-Luise, Lim Karen Phaik Har, Peters Tricia, Price Jeremy, Takizawa Hitoshi, Salmon Hélène, Idoyaga Juliana, Ruzo Albert, Lupo Philip J, Hicks M John, Shih Albert, Simko Stephen J, Abhyankar Harshal, Chakraborty Rikhia, Leboeuf Marylene, Beltrão Monique, Lira Sérgio A, Heym Kenneth M, Bigley Venetia, Collin Matthew, Manz Markus G, McClain Kenneth, Merad Miriam, Allen Carl E

Abstract excerpt

Langerhans cell histiocytosis (LCH) is a clonal disorder with elusive etiology, characterized by the accumulation of CD207(+) dendritic cells (DCs) in inflammatory lesions. Recurrent BRAF-V600E mutations have been reported in LCH. In this study, lesions from 100 patients were genotyped, and 64% c...

Topics

Animals
Antigens, CD34
Antigens, Surface
Bone Marrow
CD11c Antigen
Cell Differentiation
Cell Lineage
Child
Child, Preschool
Dendritic Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Female

Genetic Predisposition to Disease

Hematopoietic Stem Cells

Histiocytosis, Langerhans-Cell

Histocompatibility Antigens Class II

Humans

Infant

Lectins, C-Type

Source

Open in PubMed Open full text

Identifiers

PMID: 24638167
DOI: 10.1084/jem.20130977
PMCID: PMC3978272

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-24638167-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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