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Wnt5a/β-catenin axis is involved in the downregulation of AT2 lineage by PAI-1

13 Sept 2022

Abstract excerpt

Failure to regenerate injured alveoli functionally and promptly causes a high incidence of fatality in coronavirus disease 2019 (COVID-19). How elevated plasminogen activator inhibitor-1 (PAI-1) regulates the lineage of alveolar type 2 (AT2) cells for re-alveolarization has not been studied. This study aimed to examine the role of PAI-1-Wnt5a-β catenin cascades in AT2 fate. Dramatic reduction in AT2 yield was...

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PMID: 36098461
DOI: 10.1152/ajplung.00202.2022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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