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Fibrinolytic niche is required for alveolar type 2 cell-mediated alveologenesis via a uPA-A6-CD44+-ENaC signal cascade

27 Feb 2021

Abstract excerpt

COVID-19, SARS, and MERS are featured by suppressed lung fibrinolysis. The primary objective of this study was to decipher the role of the fibrinolytic niche in the progenitor alveolar type 2 (AT2) cell-mediated re-alveolarization. The expression of Plau in AT2 cells has been confirmed at the mRNA, protein, and functional level across species. We employed influenza-infected & Plau −/− mice, 3D organoids, and...

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PMID: 33640905
DOI: 10.1038/s41392-021-00511-9

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