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Article

Construction of 5-aminolevulinic acid synthase variants by cysteine-targeted mutation to release heme inhibition.

Journal of bioscience and bioengineering - 1 Nov 2022

He Guimei, Jiang Meiru, Cui Zhenzhen, Sun Xi, Chen Tao, Wang Zhiwen

Abstract excerpt

5-Aminolevulinic acid (5-ALA), a vital precursor for the biosynthesis of tetrapyrrole compounds, has been widely applied in agriculture and medicine, while extremely potential for the treatment of cancers, corona virus disease 2019 (COVID-19) and metabolic diseases in recent years. With the development of metabolic engineering and synthetic biology, the biosynthesis of 5-ALA has attracted increasing attention....

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Identifiers

PMID: 36089467
DOI: 10.1016/j.jbiosc.2022.07.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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