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5-Aminolevulinic acid synthase: mechanism, mutations and medicine.

Biochimica et biophysica acta - 11 Apr 2003

Shoolingin-Jordan Peter M, Al-Daihan Sooad, Alexeev Dmitriy, Baxter Robert L, Bottomley Sylvia S, Kahari I Donald, Roy Ipsita, Sarwar Muhammad, Sawyer Lindsay, Wang Shu-Fen

Abstract excerpt

5-Aminolevulinic acid synthase (ALAS), the first enzyme of the heme biosynthesis pathway, catalyses the pyridoxal 5'-phosphate-dependent condensation between glycine and succinyl-CoA to yield 5-aminolevulinic acid (5-amino-4-oxopentanoate). A three-dimensional structural model of Rhodobacter spheroides ALAS has been constructed and used to identify amino acid residues at the active site that are likely to be...

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PMID: 12686158
DOI: 10.1016/s1570-9639(03)00095-5

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