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Article

5-aminolevulinate synthase: catalysis of the first step of heme biosynthesis.

Cellular and molecular biology (Noisy-le-Grand, France) - 16 Feb 2009

Hunter G A, Ferreira G C

Abstract excerpt

5-Aminolevulinate synthase is a homodimeric pyridoxal 5'-phosphate-dependent enzyme that catalyzes the first step of the heme biosynthetic pathway in animals, fungi, and the alpha-subclass of the photosynthetic purple bacteria. The reaction cycle involves condensation of glycine with succinyl-coenzyme A to yield 5-aminolevulinate, carbon dioxide, and CoA. Mutations in the human erythroid-specific aminolevulinate...

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Identifiers

PMID: 19268008
PMCID: PMC2864774

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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