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Article

Shallow WGS of individual CTCs identifies actionable targets for informing treatment decisions in metastatic breast cancer.

British journal of cancer - 1 Nov 2022

Fernandez-Garcia Daniel, Nteliopoulos Georgios, Hastings Robert K, Rushton Amelia, Page Karen, Allsopp Rebecca C, Ambasager Bana, Gleason Kelly, Guttery David S, Ali Simak, Charles Coombes R, Shaw Jacqueline A

Abstract excerpt

BACKGROUND: We report copy-number profiling by low-pass WGS (LP-WGS) in individual circulating tumour cells (CTCs) for guiding treatment in patients with metastatic breast cancer (MBC), comparing CTC results with mutations detected in circulating tumour DNA (ctDNA) in the same blood samples. METHODS: Across 10 patients with MBC who were progressing at the time of blood sampling and that had >20 CTCs detected by...

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Identifiers

PMID: 36088510
DOI: 10.1038/s41416-022-01962-9
PMCID: PMC9643413

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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