Article
A novel role for histone deacetylase 6 in the regulation of the tolerogenic STAT3/IL-10 pathway in APCs.
Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 2014
Cheng Fengdong, Lienlaf Maritza, Wang Hong-Wei, Perez-Villarroel Patricio, Lee Calvin, Woan Karrune, Rock-Klotz Jennifer, Sahakian Eva, Woods David, Pinilla-Ibarz Javier, Kalin Jay, Tao Jianguo, Hancock Wayne, Kozikowski Alan, Seto Edward, Villagra Alejandro, Sotomayor Eduardo M
Abstract excerpt
APCs are critical in T cell activation and in the induction of T cell tolerance. Epigenetic modifications of specific genes in the APC play a key role in this process, and among them histone deacetylases (HDACs) have emerged as key participants. HDAC6, one of the members of this family of enzymes, has been shown to be involved in regulation of inflammatory and immune responses. In this study, to our knowledge we...
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