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Stromal FAP is an independent poor prognosis marker in non-small cell lung adenocarcinoma and associated with p53 mutation.

Lung cancer (Amsterdam, Netherlands) - 1 May 2021

Moreno-Ruiz Pablo, Corvigno Sara, Te Grootenhuis Nienke C, La Fleur Linnéa, Backman Max, Strell Carina, Mezheyeuski Artur, Hoelzlwimmer Gabriele, Klein Christian, Botling Johan, Micke Patrick, Östman Arne

Abstract excerpt

OBJECTIVES: Fibroblasts regulate tumor growth and immune surveillance. Here, we study FAP, PDGFβR and α-SMA fibroblast markers in a well-annotated clinical cohort of non-small-cell lung cancer (NSCLC) for analyses of associations with immune cell infiltration, mutation status and survival. MATERIALS AND METHODS: A well-annotated NSCLC cohort was subjected to IHC analyses of stromal expression of FAP, PDGFβR and...

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PMID: 33706022
DOI: 10.1016/j.lungcan.2021.02.028

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