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Using a Polygenic Score to Predict the Risk of Developing Primary Osteoporosis

2 Sept 2022

Abstract excerpt

Osteoporosis (OP) is a multifactorial bone disease belonging to the metabolic osteopathies group. Using the polygenic score (PGS) approach, we combined the effects of bone mineral density (BMD) DNA loci, affecting osteoporosis pathogenesis, based on GEFOS/GENOMOS consortium GWAS meta-analysis. We developed models to predict the risk of low fractures in women from the Volga-Ural region of Russia with efficacy of...

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PMID: 36077420
DOI: 10.3390/ijms231710021

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