Article

Respiratory mucosal administration of DNA aptamer nanomaterials protects against antigenically diverse SARS-CoV-2 variants

2024-06-03

Abstract excerpt

The ongoing COVID-19 pandemic has highlighted the need for innovative therapeutic strategies to combat rapidly evolving pathogens that challenge the efficacy of traditional vaccines and monoclonal antibody treatments. Here, we explored the potential of TMSA52, a previously described homotrimeric DNA aptamer as a universal prophylactic and therapeutic agent against SARS-CoV-2. TMSA52 demonstrates exceptional bindin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 491c0136-3676-5308-83e2-af9fe51001fc
DOI: 10.1101/2024.05.31.596896

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Respiratory mucosal administration of DNA aptamer nanomaterials protects against antigenically diverse SARS-CoV-2 variantsDOI 10.1101/2024.05.31.596896Read

Spherical Neutralizing Aptamer Inhibits SARS-CoV-2 Infection and Suppresses Mutational Escape.Semantic proximity Read

A novel G-quadruplex aptamer-based spike trimeric antigen test for the detection of SARS-CoV-2Semantic proximity Read

Spatial- and Valence-Matched Neutralizing DNA Nanostructure Blocks Wild-Type SARS-CoV-2 and Omicron Variant InfectionSemantic proximity Read

Next‐Generation Vaccines: Nanovaccines in the Fight against SARS‐CoV‐2 Virus and beyond SARS‐CoV‐2Semantic proximity Read

Nanobody Repertoires for Exposing Vulnerabilities of SARS-CoV-2Semantic proximity Read

Spherical nucleic acids as an infectious disease vaccine platformSemantic proximity Read

Nano-Enabled Antivirals for Overcoming Antibody Escaped Mutations Based SARS-CoV-2 Waves.Semantic proximity Read

Broadly neutralizing aptamers to SARS-CoV-2: A diverse panel of modified DNA antiviral agentsSemantic proximity Read

Aptamer‐based strategies against SARS‐CoV‐2 virusesSemantic proximity Read

Oligonucleotide aptamers for pathogen detection and infectious disease controlSemantic proximity Read

DNA origami vaccine (DoriVac) nanoparticles improve both humoral and cellular immune responses to infectious diseasesSemantic proximity Read

A Multivalent Vaccine Based on Ferritin Nanocage Elicits Potent Protective Immune Responses against SARS-CoV-2 Mutations.Semantic proximity Read