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Article

OGG1 deficiency alters the intestinal microbiome and increases intestinal inflammation in a mouse model.

PloS one - 1 Jan 2020

Simon Holly, Vartanian Vladimir, Wong Melissa H, Nakabeppu Yusaku, Sharma Priyanka, Lloyd R Stephen, Sampath Harini

Abstract excerpt

OGG1-deficient (Ogg1-/-) animals display increased propensity to age-induced and diet-induced metabolic diseases, including insulin resistance and fatty liver. Since the intestinal microbiome is increasingly understood to play a role in modulating host metabolic responses, we examined gut microbial composition in Ogg1-/- mice subjected to different nutritional challenges. Interestingly, Ogg1-/- mice had a...

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Identifiers

PMID: 31935236
DOI: 10.1371/journal.pone.0227501
PMCID: PMC6959583

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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