Article
Human intelectin-1 (ITLN1) genetic variation and intestinal expression.
Scientific reports - 18 Jun 2021
Nonnecke Eric B, Castillo Patricia A, Dugan Amanda E, Almalki Faisal, Underwood Mark A, De La Motte Carol A, Yuan Weirong, Lu Wuyuan, Shen Bo, Johansson Malin E V, Kiessling Laura L, Hollox Edward J, Lönnerdal Bo, Bevins Charles L
Abstract excerpt
Intelectins are ancient carbohydrate binding proteins, spanning chordate evolution and implicated in multiple human diseases. Previous GWAS have linked SNPs in ITLN1 (also known as omentin) with susceptibility to Crohn's disease (CD); however, analysis of possible functional significance of SNPs at this locus is lacking. Using the Ensembl database, pairwise linkage disequilibrium (LD) analyses indicated that...
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